ML1 [FBbt_00052137]

Optic lobe neuron that has its soma in the anterior medulla cell body rind, multicolumnar dendritic innervation of the medulla, and an axon that reaches the anterior lobula without passing through the second optic chiasm (Kind et al., 2021). Its dendritic arborization spans approximately 20 optic columns, ramifying in layers M1-4 and M8 from vertical processes (Kind et al., 2021). It receives synaptic input from R8 photoreceptors, mainly in pale optic columns (Kind et al., 2021). Its axon leaves the distal medulla and travels anteriorly to reach layer 6 of the lobula, where it has postsynapses in a few columns (Kind et al., 2021; Nern et al., 2025). In a subpopulation of these cells its axon also innervates the central brain (Kind et al., 2021). It is predicted to be cholinergic (Eckstein et al., 2024; Nern et al., 2025). There are around 45 of these cells per optic lobe (Kind et al., 2021; Nern et al., 2025).
ML1 ML1 ML1 ML1

ML1

ID: FBbt_00052137

Adult Cholinergic Nervous system Visual system

Optic lobe neuron that has its soma in the anterior medulla cell body rind, multicolumnar dendritic innervation of the medulla, and an axon that reaches the anterior lobula without passing through the second optic chiasm (Kind et al., 2021). Its dendritic arborization spans approximately 20 optic columns, ramifying in layers M1-4 and M8 from vertical processes (Kind et al., 2021). It receives synaptic input from R8 photoreceptors, mainly in pale optic columns (Kind et al., 2021). Its axon leaves the distal medulla and travels anteriorly to reach layer 6 of the lobula, where it has postsynapses in a few columns (Kind et al., 2021; Nern et al., 2025). In a subpopulation of these cells its axon also innervates the central brain (Kind et al., 2021). It is predicted to be cholinergic (Eckstein et al., 2024; Nern et al., 2025). There are around 45 of these cells per optic lobe (Kind et al., 2021; Nern et al., 2025).

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## Classification

Relationships

Alternative Names

Synonym Scope Reference
MeLo1 exact synonym Berg et al., 2025
adult medulla-lobula neuron MeLo1 exact synonym Nern et al., 2025
MeLo1 exact synonym Nern et al., 2025
medulla-to-lobula cell ML1 exact synonym Kind et al., 2021
adult ML1 neuron exact synonym Kind et al., 2021
ML1 exact synonym Kind et al., 2021
MLt1 exact synonym Bates et al., 2025
MLt1 exact synonym Schlegel et al., 2024
CB3833 exact synonym Schlegel et al., 2024
MLt1 exact synonym Matsliah et al., 2024
amacrine-like cell related synonym Kind et al., 2021
MeLo1 exact synonym
adult CB3833 neuron exact synonym Schlegel et al., 2024
amacrine-like cell related synonym Gao et al., 2008

List all available images of ML1 (323 total)

Thumbnail Name Tags
MeLo1_L (MaleCNS:220992) Nervous_system, Visual_system, Adult, Cholinergic
MeLo1_L (MaleCNS:35391) Nervous_system, Visual_system, Adult, Cholinergic
MeLo1_R (MaleCNS:27669) Nervous_system, Adult, Visual_system, Cholinergic
MeLo1_R (MaleCNS:35445) Nervous_system, Visual_system, Adult, Cholinergic
MeLo1_R (MaleCNS:39072) Nervous_system, Visual_system, Adult, Cholinergic

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Expression patterns overlapping ML1 (1 total)

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Transgene expression in ML1 (1 total)

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Downstream connectivity classes for ML1 (448 total)

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Upstream connectivity classes for ML1 (233 total)

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